Tetraazaindenes derived from dihydropyrazines with DNA strand-breaking activity.
نویسندگان
چکیده
Dihydropyrazines (DHPs), which exhibit DNA strand-breaking activity and other biological activities associated with the generation of radical species, reacted with thiourea to give tetraazaindene (TAI) derivatives, despite thiourea is a well known radical scavenger. The structural determination of the TAIs was carried out and formation mechanism of TAI was investigated.
منابع مشابه
Biol. Pharm. Bull. 30(9) 1663—1667 (2007)
of dihydropyrazines (DHPs) such as 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP), which causes DNA strand breakage in the plasmid pBR322. We showed that DHPs inhibit growth and cause mutagenesis in Escherichia coli and that Me-DHP is cytotoxic and genotoxic in E. coli due to the production of radical species in the presence of Cu . Phenyl substituted dihydropyrazines (Ph-DHPs) have much higher DNA ...
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 57 12 شماره
صفحات -
تاریخ انتشار 2009